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Dermatopathology

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Soft Tissue Myoepithelioma

Myoepithelioma of soft tissue.

The findings of a organoid monomorphic glomoid appearing tumor that shows a combined epithelial and smooth muscle phenotypic profile is diagnostic of myoepithelioma of soft tissue. They do exhibit a characteristic cytogenetic profile mainly the EWSR1 gene rearrangement although a variety of different fusion partners such as EWSR1-ZNF444 fusion have been described. There are two broad categories namely benign and malignant variants.

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