The Weill Cornell Comprehensive Dermatopathology Service provides the full range of services to evaluate skin tissue specimens, including:
- Routine H and E Interpretation.
- Electron Microscopy to diagnose Epidermolysis bullosa, indeterminate cell proliferative disorder, Langerhans cell histiopathy, congenital ichythosis, Cadasil's disease.
- B and T cell Gene Rearrangement Studies.
- Fluorescent In Situ Hybridization.
- In Situ Hybridization for comprehensive HPV typing.
- Comprehensive Immunohistochemistry, including all lymphocyte and myeloid markers and the novel prognostic melanocyte marker soluble adenylyl cyclase antibody/R21 and various markers to assess microvascular injury conditions (including Rho kinase, caspase 3, MXA, C5b-9, C3d, and C4d).
- Direct/indirect Immunofluorescence representing the most comprehensive panel of immunoreactants (including of IgG, IgA, igM, C3, C3d, C4d, C1q, C5b-9 and fibrinogen).
- Cytogenetic testing.
- BRAF mutational analysis.
- Salt Split Skin Assay, for distinction of Bullous Pemphigoid and Epidermolysis bullosa acquista.
- Indirect Immunofluorescent Testing, including assessment of circulating antibodies directed against endothelium and pemphigus/pemphigoid antigens.
- Cutaneous neuropathology to assess for the etiologic basis of certain stroke syndromes such as Cadasil's disease and antiphospholipid antibody syndrome, demyelinating syndromes as well as small fiber neuropathy.
- Podiatric pathology.
- Clinicopathological correlation.
Our service autofaxes all reports and can provide duplicate slides and articles upon request.