Dermatopathology

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Pseudosarcomatous Polyp

The findings are compatible with a cutaneous pseudo-sarcomatous polyp. The entity was first recognized in 1996 when long-standing polypoid skin lesions with cytologic atypia but a benign clinical course were described. The lesions typically show CD34 and Factor XIIIA positivity. Some authors have postulated that perhaps the pseudo-sarcomatous polyps of the skin represent degenerated dermal spindle cell lipomas. There is a subset of so-called pleomorphic fibromas that likely represent pseudo-sarcomatous fibroepithelial polyps as sometimes the so-called pleomorphic fibromas exhibit a polypoid configuration. The key in recognizing the diagnosis is the bland architecture. These lesions do behave in a benign fashion after local excision.

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