Dermatopathology

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Desmoplastic Trichilemmoma

Trichilemmomas typically present as solitary lesions on the face but when multiple can be associated with Cowden syndrome. The typical histologic features as seen in this case are: overall circumscription, endophytic growth, peripheral palisading, one or more connections to the epidermis, thickened basement membranes, glycogenated cuboidal cells with clear cytoplasm and round nuclei, squamous whorls and keratinization.

Weill Cornell Medicine Dermatopathology 1300 York Avenue
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