Dermatopathology

Dermatofibrosarcoma Protuberans

The findings are diagnostic of Dermatofibrosarcoma Protuberans.

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Slide 1: The shaved biopsy specimen shows an acanthotic epidermis. Within the dermis there is an spindled cell neoplasm that spans the entire dermis. A 42-year-old female presented with an irregular brownish red plaque under the right breast growing in size for 9 years.
Slide 2: The spindled cell neoplasm is manifesting a storiform growth pattern along with entrapment of adipocytes resembling a honeycomb architecture.
Slide 3: This image shows the honeycomb architecture.
Slide 4: Cytomorphologically the cells are monomorphic appearing spindled with scant eosinophilic cytoplasm and hyperchromatic nuclei. There is minimal pleomorphism. No significant mitoses are identified.
Slide 5: The immunohistochemical studies have been performed and revealed the spindled cell neoplasm is strongly positive for CD34.
Slide 6: The FACTOR XIIIA preparation is negative within the tumor cells.
Slide 7: Ki67 proliferation index is roughly 1-2%.
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